Gene implicated in faulty immune response

Research from McGill University Health Centre has shown a link between a gene mutation present in 25% of Crohn's patients and a lack of immune response to mycobacteria. When this connection is fully understood it may lead to new therapies for Crohn's targeting the NOD2 gene involved.

As explained by the lead researcher, Dr. Marcel Behr:

"Now that we have a better understanding of the normal role of NOD2, we think that a mutation in this gene prevents mycobacteria from being properly recognized by the immune system," explained Dr. Behr. "If mycobacteria are not recognized, the body cannot effectively fight them off and then becomes persistently infected."

The full article is published in the Journal of Experimental Medicine (full article requires subscription).